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An acute increase in oxidative damage altered in vivo BMI1 activity by recruiting BMI1 away from canonical DNA targets.
The hand-wringing in recent weeks over a study that documented an acute increase in the prescription of psychiatric medications -- primarily stimulants and antidepressants -- for preschoolers over a five-year period would suggest just that.
In a study last month in The Journal of the American Medical Association, researchers reported that there had apparently been an acute increase in the number of preschoolers taking psychotropic drugs, particularly stimulants like Ritalin and antidepressants like Prozac.
In a somewhat lampooned paper – it won an IgNobel award in September for "improbable research" – Australian and American researchers examined the "effect of acute increase in urge to void on cognitive function in healthy adults".
Mammalian fetal heart resides in a relatively hypoxic environment, and in the 2 weeks after birth, there is an acute increase in ROS (Supplementary Figure 1A) and DNA damage.
We also observed an acute increase in the expression of this subunit in descending neurons after SCI, which further supported the possible role of GABA and GABAB receptors in promoting the survival and regeneration of these neurons.
The acute increase in the expression of the gabab1 subunit in descending neurons and the massive release of GABA after SCI37 appears as one of the mechanisms favouring neuronal survival and axonal regeneration after SCI in lampreys.
To evaluate the effect of an acute increase in ROS levels in cardiac progenitor cells in vivo, we analyzed the differentiation status of Bmi1-derived cells between postnatal days 1 and 14.
The early acute increase in risk associated with high temperature was followed by a deficit, thus suggesting evidence of a harvesting effect.
We found an acute increase in cerebral Aβ levels ranging from 24 h to one month following TBI (overall log OR = 2.97 ± 0.40, p < 0.001).
We conclude that the acute increase in plasma nitrite seen after a nitrate load is critically dependent on nitrate reduction in the oral cavity by commensal bacteria.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com