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It's possible that along the way many thought Bowe was simply a controlling hothead and couldn't foresee such an acute escalation.
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Despite relative dose escalation, acute and late toxicity can be reduced.
The training in geriatric pain management focuses on appropriate short- and long-acting drugs for the treatment of acute and chronic pain, dose escalation, analgesic escalation and management of side effects.
Because many cases of migraine are chronic and intermittent, it is recommended that patients undergo correct pharmacologic management and retain the prescribed treatment to avert or relieve debilitating pain, prevent escalation to acute medications, and improve day-to-day functioning[3].
Increased urinary frequency and urgency due to diuretic dose escalation during acute heart failure episodes may motivate patients to consult for incident symptoms of overactive bladder.
The toxicities reported from the randomized trials suggest that hyperfractionation with dose escalation increases acute mucosal toxicity, but does not seem to induce significantly more severe late effects compared with conventional fractionation.
At 53 years of age the patient developed acute autoimmune hepatitis that required escalation of immunosuppressive treatment.
Colchicine is a purely prophylactic treatment in FMF, and introduction or dose escalation during an acute FMF attack is not generally effective.
In addition, changes in MFI scales were assessed in subgroups of patients who were pain responders, those who reported 'feeling much better', and those who required a dose escalation in the acute phase.
Subgroup analyses were conducted on acute-phase mean changes in MFI scale ratings in pain responders and non-responders, patients with endpoint PGI-I of not greater than 2 or greater than 2, and before and after dose escalations in the acute phase.
Affected infants experience a rapid escalation of potentially lethal acute symptoms following exposure to milk.
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