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Although some patients have acute deficits that appear and improve over time, other patients have progressive declines in neurocognitive function that are chronic.
It also glosses over an awkward fact for Republicans: the acute deficits looming for Medicare became far worse as a result of the prescription drug bill that President Bush supported and signed.
Thus, incidence of acute deficits increases with progressing underlying pathology (Fisher's exact test, p <0.01).
The acute deficits triggered in this study were reversible and did not cause additional loss of synaptic terminals but LPS challenges have been deliberately mild here to facilitate cognitive testing.
Both data sets demonstrate increasing susceptibility to acute deficits with increasing underlying cognitive or neurodegenerative pathology, providing empirical human and animal evidence that dementia-associated risk is not binary but rather is on a continuum.
Implications and future directions This study supports the hypothesis that RTT-associated respiratory dysfunctions in Mecp2 mutant mice are linked to acute deficits in BDNF-TrkB signandng and that these dysfunctions can be rescued by the use of a small-molecule BDNF loop-domain mimetic.
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It is well suited to the management of major incidents where an acute deficit of healthcare professionals can be ameliorated by teleconsultation [[56]].
Due to the inherent plasticity of brain regions after damage, one possibility is that an initially acute deficit in memory metacognition was compensated by reorganization distant from the lesion site, leading to an apparent dissociation between domains.
However, they can manifest neurological symptoms, for example, because of intra-lesional bleed these may present as acute neurological deficits and altered mentation, or may even present with a more indolent course with gradually worsening neurological deficits.
Injury from blunt head impacts causes acute neurological deficits and may lead to chronic neurodegeneration.
These findings will assist in interpreting acute motor deficits, predicting the time course and expected level of functional recovery, and designing therapeutic strategies in patients with localized frontal lobe injury or neurosurgical resection.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com