The phrase "acute defect" is correct and usable in written English.
It can be used in contexts related to medicine, engineering, or quality control to describe a serious or severe flaw or issue.
Example: "The inspection revealed an acute defect in the structural integrity of the building, necessitating immediate repairs."
Alternatives: "serious flaw" or "critical defect."
Anti-TGFβ blocking antibodies (Fig. 7B), but not control IgGs (Fig. 7C), induced acute defects in angiogenesis.
However, L. major infected WSX-1-/ mice display acute defects in IFN-γ production and lesion resolution (Fig. 3) [ 37, 43, 44].
Thus, while WSX-1-/ mice exhibit acute defects in the production of IFN-γ during infection with L. major, these animals also develop exaggerated Th1 responses upon infection with T. gondii and T. cruzi (Fig. 3).
In fact, despite acute defects in pathogen induced IFN-γ production, WSX-1-/-mice eventually develop the Th1 responses required for control of L. major and BCG infections (Fig. 3) [ 37, 44].
Although both subchondral bone resorption and the synthesis of new woven bone were observed, the resorption was definitively stronger during the first three weeks of repair, as evidenced by the larger size of the treated holes compared to acute defects.
In comparison with tendinopathy of the patellar tendon, acute defects of the patellar tendon are commonly iatrogenic when the tendon is harvested for the purposes of anterior cruciate ligament reconstruction surgery.
This study has demonstrated that the combination of rhFGF18 and a collagen-GAG osteochondral scaffold can produce objective improvements in osteochondral repair when incorporated in an acute osteochondral defect model in sheep, although topographic variation may exist between the MFC and LTS.
In acute chondral defect models in the dog [ 77] and goat [ 78], BMP-7 regenerated articular cartilage, increased repair tissue formation and improved integrative repair between new cartilage and the surrounding articular surface.
In the present study, we aimed to block the MDMA-induced acute memory defect by giving participants a cortisol synthesis inhibitor (metyrapone) together with a single dose of MDMA.
The attempt to use higher MOs concentrations resulted in acute generalized defects that impeded additional analysis of the morphants, as previously reported for the single prox1a MO injection [10].
