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Dry powder inhalers (DPIs) were developed with the intention of preventing errors in the co-ordination of actuation and inhalation.
Both BAIs and DPIs are actuated by the patient's inhalation maneuver, while MDIs require coordination by the patient of actuation and inhalation.
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The compliance of the subjects to ICS was evaluated with a Chronolog (Medtrac) that registered time of MDI actuation and quality of inhalation.
Major reasons for this are failure by patients to co-ordinate actuation with inhalation and failure to use a slow and deep inhalation [ 1, 3, 4].
Acute toxicity; oral, dermal, and inhalation toxicities.
Several routes of exposure to nanomaterials exist; the most important being dermal contact and inhalation.
With a DPI, the act of inhalation de-aggregates ('breaks up') and releases the metered dose of drug, thereby removing the need for a patient to coordinate actuation with inhalation.
Animals and inhalation exposure.
Thirty minutes after inhalation of two puffs of ipratropium bromide (18 μg per actuation) and albuterol sulfate (Combivent®, Boehringer Ingleheim, Germany, 103 μg per actuation) in a pressurized metered-dose aerosol unit, a post-bronchodilator spirometry was performed.
Smiths, based in London, is interested in the unit's actuation and power-management businesses, said Keith Buther-Wheelhouse, the chief executive.
These processes lead to photoinduced plasticity, actuation, and equilibrium shape changes without residual stress.
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