The phrase "activity was demonstrated when" is correct and usable in written English.
It can be used to indicate a specific instance or condition under which an activity took place or was shown.
Example: "The effectiveness of the new teaching method was demonstrated when students improved their test scores significantly."
Alternatives: "activity was shown when" or "activity was exhibited when".
However, it is interesting to note that its broad activity profile against HDACs, which depends on zinc chelation for activity, lacks therapeutic efficacy as monotherapy in patients with multiple myeloma, whereas synergistic activity has been demonstrated when used in combination with other drugs targeting different hubs of the tumor network [29].
It was found that the enhanced electrocatalytic activity can be demonstrated when high-conductive graphene flake was introduced into MoS2 film.
Full estrogenic activity was demonstrated for BPA when it was tested for use as a pharmaceutical drug in 1936, which should have precluded its use in the wide range of products that results in continuous exposure (Stahlhut et al. 2009).
Under the same growth conditions, increased p53 expression, but not enhanced p38 activity, was demonstrated in MCF-7 when treated with doxorubicin, confirming a p53-mediated response to doxorubicin in cells containing a wild-type p53 gene product (Bowcock, 1999; Roses, 1999; Perego et al, 2001).
Also, the activity of bevacizumab has been demonstrated when administered as a single agent [ 12].
In most of the studies, the inhibitory activity of tea could be demonstrated when tea preparations were given either during or after the carcinogen treatment period.
However, when AHR100 cells were transfected with XRE and treated with 5F 203 (1 μ M), XRE-luciferase activity was demonstrated to be only approximately 1.7-fold higher than control.
The relationship between the structural properties of ligands, especially when described with pharmacophore descriptors, and their biological activity is demonstrated to be useful for drug discovery applications.
Low clinical activity was previously demonstrated when targeting TS in ovarian cancer with the polyglutamatable TS inhibitor raltitrexed (RTX) demonstrating 7 and 11% response rates (Gore et al, 1995; Muggia et al, 1998), and 5-FU a 14% response rate (Look et al, 1995) in relapsed disease.
In animal experiments a rapid antiepileptic activity has been demonstrated, especially when used in combination with diazepam [ 111].
