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In normal mode, three vibration activities (locomotor activity, tremor and twitch) are auto-analyzed every 10 min.
Single animals were observed in a transparent plastic cage [17 cm (d) × 27 cm (w) × 20 cm (h)] for 3 min for any signs of stereotypy, convulsions, excessive activity, tremor, freezing and grooming.
4 Subjects were not included if they had a history of head trauma with loss of consciousness, psychotic or major depressive disorder according to the Diagnostic and Statistical Manual of Mental Disorders, 4th edition criterion, or aberrant motor activity (tremor, rigidity, Parkinsonism) as defined by the Movement Disorder Society Unified Parkinson Disease Rating Scale.
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These include abnormal gait, reduced spontaneous activity, tremors and hindlimb clasping.
Other electrophysiological studies have calculated the oscillatory activity (at tremor or double tremor frequency) of single neurons or larger groups of neurons, for example using subcortical DBS electrodes or cortical magnetoencephalography recordings (Levy et al., 2000; Timmermann et al., 2003).
Importantly, the synchronicity of basal ganglia and thalamic activity to tremor varies between regions.
Overall, very little work has been done in terms of demonstrating a correlation between single unit or LFP activity and tremor severity over time.
However, although a relationship between beta activity and tremor has been reported (Levy et al., 2000), doubt has since been cast on the validity of this observation by the same group (Weinberger et al., 2006).
Notably, the active periods of tremor activity identified in this study are not coincident with teleseismic large earthquakes (Mw > 5) in the Harvard CMT catalog (Fig. 2(c)).
Considering such a hypothetical scenario, it is important to note that the eruption of a supervolcano is not only very unlikely at this time, but precursory geological activity (like tremors) would happen months, even years, before any visible volcanic activity would be noted.
Tremor syndromes are often associated with cortical activity at both tremor frequency and at double this frequency [ 6].
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