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Any activity that activates those pathways reinforces the pleasurable behavior.
Myotubes were treated for 48 hours with 6-BromoIndirubin-3'-Oxime (BIO), a selective inhibitor of GSK-3 activity that activates the Wnt/β-catenin pathway [24].
Spontaneous upregulation of the DNA-PKcs-JNK pathway in RA T cells indicated continuous DNA repair activity that activates cell-internal stress kinases and jeopardizes T-cell survival.
The oncogenic potential of ALK fusions relies on their hyperactive tyrosine kinase activity that activates interconnected signaling pathways common to many oncogenic kinases.
Activation of JNK in obesity may be a particular consequence of ER stress since IRE-1 has, apart from endoribonuclease activity, also kinase activity that activates JNK (Fig. 4).
In addition, the activation of Wnt signaling by 6-bromoindirubin-3′-oxime (BIO), which is a selective inhibitor of glycogen synthase kinase 3 (GSK-3) activity that activates Wnt signaling, increased TNF-α expression and promoter activity.
Similar(51)
DOCK9 (OMIM 607325) encodes a member of the DOCK protein family with GTP/GDP exchange factor activity that specifically activates G-protein CDC42 [ 202].
The 34 amino acid peptide Nisin A was found to have surprisingly strong IRI activity that was activated by a change in pH and protonation of its histidine residues.
Although p85β localized to cell adhesions independently of PI3K activity that is activated by extracellular signals, generation of F-actin-positive adhesions required associated PI3K activity; additionally, despite p85β expression increased basal GTP-Cdc42 levels, optimal Cdc42/Rac activation was only detected in p85β-expressing cells after PDGF treatment.
Neutrophils in buffer may have very low pseudopod-activating activity that is silenced by strong uniform inhibition; in combination with strong gradient-induced local activators this leads to gradient-induced pseudopodia.
Second, we envisioned that a C1_5 protein might have a second domain with enzyme activity that might be activated by DAG to post-translationally modify proteins involved in endocytosis thereby enhancing Tf uptake.
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