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These findings suggested that cardiomyocytes with reduced Notch activity secondary to transgene activation could activate compensatory signalling pathways to stimulate myocyte division.
Here we report an update on safety endpoints (primary), clinical activity (secondary) and the exploratory endpoints of progression-free survival, duration of response and time to response.
Their data are however still controversial since Matthiesen et al. and Russwurm et al. did not observe any changes in PDE10A activity secondary to cAMP alterations (Matthiesen and Nielsen 2009; Russwurm et al. 2015).
While training increases VO2max and fitness in younger and older adults [28], [29], it does not increase total daily activity in older people, mostly likely because of compensatory decreases in everyday activity secondary to exercise fatigue [29], [30].
In isolated mitochondria, the integrity of the mitochondrial network and dynamics inside the cell is not maintained and therefore defects in mitochondrial activity secondary to abnormal mitochondrial dynamics are not detectable.
In this study, SO subjects had low levels of physical activity secondary to osteoarthritis, a pathology manifested solely due to daily mechanical stress-mediated wear and tear over the lifespan of an individual [62], [63].
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Pain was defined as 'interference in day-to-day activities secondary to pain'.
The choice for the unit of analysis defined the focus on primary activities: secondary activities may be underrepresented.
Also, while mutations and/or overexpression are linked to their tumorigenic activities, secondary modifications are essential for their normal and pathological activities [ 32, 66].
Prediction results are affected by evaluation of important degree from the agent, such as key collaborative activities and secondary collaborative activities [20, 21].
Increasing PW, more nerve endings are activated, see Fig. 4b, which increases the activity of secondary neurons.
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