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Inhibition of HDAC enzymatic activity reverts the leukemic phenotype in vitro and therefore represents a plausible strategy for antileukemic therapy.
The activity reverts to the original level within 2 3 days if the agent is withdrawn.
While colloidal exclusion almost certainly accounts for loss of activity, the fact that activity reverts to zero rather than flat-lining at an apparent maximum is intriguing.
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The firing activity reverted quickly to the background level as soon as the contact with the stimulus was broken except at the lowest dilution (1∶10).
The majority of gene expression regulation in replicative senescence was shown to occur due to telomere shortening, as exogenous telomerase activity reverted most of these changes.
Rhythmic whisking lasted up to several seconds (3-5 sec), and when vibrissae movement ceased, burst firing also stopped, and TMne activity reverted to a tonic firing pattern, slowly returning to the baseline firing rate.
Conversely, if the euro-zone economies experience a recession an economic downturn associated with declining output and economic activity the ECB steps in by pumping more euros into the market in order to fuel economic activity and revert the effects of the recession.
I knew the mutations were central to antibody function because they lost their binding and neutralizing activity when reverted to their germline sequences (3, 7).
Moreover, NVP-BEZ235 can sensitize vincristine-resistant Jurkat cells, indicating that inhibition of mTORC1 activity may revert chemoresistance.
However, PAL activity levels reverted to their initial values in intact tissues after 14 days, although such levels were not maintained afterwards.
This model of attachment and SAC control predicts the existence of a crucial phosphatase activity to revert the initial state of kinetochore phosphorylation when the distance of kinetochore substrates from Aurora B increases.
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