Sentence examples for activity receptor from inspiring English sources

Other compounds that may be translated into upcoming trials include mammalian target of rapamycin (mTOR) inhibitors, PI3K pathway inhibitors, anti-microtubular agents, cell cycle protein inhibitors, disruptors of osteoclast activity (receptor activator of nuclear factor-κB ligand inhibitors and bisphosphonates), immune strategies, and other targeted agents.

By providing information on three levels of hormonal activity (receptor binding, transcriptional activation, and an in vivo effect in an estrogen-responsive tissue), an informative profile of estrogenic activity is obtained with a reasonable investment of resources.

PP2 and SI-1 are known also to inhibit the kinase activity Receptor Interacting Protein 2 (RIP2), which shares a very similar active site (Bain et al., 2007).

The structure of the conjugate determines the profile of biological activity, receptor selectivity, and physical properties such as water solubility.

A well-designed cell-based assay should be able to evaluate, indirectly or directly, all three steps in BoNT activity: receptor binding, internalization and translocation, and catalytic activity.

Future experiments with HPLC purified radiotracer in competition binding studies in vitro and in vivo, and investigation in a high somatostatin receptor expressing tumour mouse model will have to clarify, whether specific activity, receptor affinity and/or in vivo kinetics of [Al18F]2 can explain these results.

Because arginine is present in high abundance in the functional sites of many proteins, GO may disrupt their functionality by reducing enzymatic activity, receptor-ligand or protein-nucleotide binding.

Whereas some mutations in the LDLR gene completely eliminate LDLR function (<2 % of normal activity; receptor-negative or null mutations), others reduce function by up to 75%% (2 25 % of normal activity; receptor-defective mutations) [ 24].

In order to increase its activity, receptor-specific ligands and agonistic antibodies have been developed and some cancer types, including pancreatic cancer, have been reported to respond preferentially to TRAIL-R1 triggering.

Many molecular functions that are common in N-glycoproteins were enriched in our dataset, including receptor activity, transporter activity, TMD receptor activity, TMD transporter activity, peptidase activity, and ion binding.

Their inhibiting activity on receptor IL-2 Itk correlates descriptors based on topology and hydrophobicity.