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The CoMFA-derived QSARs may be useful in examining the estrogenic activity of a wider range of phenyl-substituted hydrocarbons of environmental concern.
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Toluene dose-dependently alters the activity of a wide range of ion channels.
The objective of this work is to evaluate catalytic activity of a wide range of carbon materials for methane decomposition reaction and determine major factors governing their activity.
Directed evolution techniques have been used to improve the activity of a wide range of enzymes but can be difficult to apply when the enzyme is used in whole cells.
The team took samples of corals from both the highly variable and the moderately variable pools and subjected them to thermal stress experiments under laboratory conditions while monitoring the levels of expression, or activity, of a wide range of genes.
Dr Simon Archer, who helped run the experiment, found that getting an hour's less sleep a night affected the activity of a wide range of our volunteers' genes (around 500 in all) including some which are associated with inflammation and diabetes.
UBL modified proteins are known to influence the activity of a wide range of cell signaling pathways[28], [29].
High mobility group proteins (HMGA) regulate the activity of a wide variety of genes by changing the DNA conformation of their target genes.
Signaling processes mediated by small G proteins can impinge upon the activity of a wide variety of membrane-resident ion channels.
Under hypoxic conditions, dimerisation of the stabilised HIF-alpha subunit with the HIF-beta subunit enables the transcriptional activity of a wide range of genes including those involved in cellular metabolism, hypoxia tolerance and angiogenesis, such as vascular endothelial growth factor (VEGF) and erythropoietin (EPO) [6] [8].
These strains have been shown to be sensitive to the mutagenic activity of a wide range of chemical classes [ 20].
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