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These changes may lead to the increased production of ROS and increased membrane permeability that can potentiate the activity of a broad range of antibiotics against Gram-negative bacteria in different metabolic states, as well as to restore antibiotic susceptibility to a resistant bacterial strain.
Numerous preclinical studies have demonstrated that inhibition of autophagy enhances the activity of a broad array of anticancer agents.
This study was designed to monitor the longitudinal activity of a broad panel of comparator agents, including the glycylcycline antimicrobial tigecycline, against a collection of clinically important pathogens.
Although CKIs modulate the activity of a broad variety of substrates, and multiple isoforms exist in both animals and plants, they have specific roles at certain developmental stages.
In addition to its directs effects on components of chromatin, PARP-1 may also modulate the localization and activity of a broad array of histone-modifying and nucleosome remodeling enzymes.
The Hsp90 chaperone complex maintains the correct folding, cellular localization and activity of a broad range of protein clients that are implicated in various signal transduction pathways involved, among others, in cell proliferation, differentiation and survival [ 7, 10].
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Therefore, it is likely that the low methanol dehydrogenase activity of P. putida S12 results from a side activity of a broad-specificity alcohol dehydrogenase.
gambiae that showed species-specific expansion and led to the hypothesis of a receptor activity for a broad spectrum of antigens for AgMDL1 of An. gambiae[ 27].
Several studies have shown that MSCs suppress the proliferation and activities of a broad range of immune cells, including T cells, antigen-presenting cells, natural killer (NK) cells and B cells, probably through release of cytokines including indoleamine 2,3-dioxygenase, transforming growth factor beta-1, prostaglandin E, and nitric oxide [6], [28], [30].
This latter finding is consistent with HD-common motifs that mediate the activities of a broad spectrum of HDs, including members of the Hox family (Capovilla et al., 2001; Enriquez et al., 2010).
Moreover, the catalyst exhibited effective catalytic activity for a broad range of epoxides with a reasonable reusability.
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