The high activity is not solely explained by the enrichment of the substrate levels (APP CTFs) since the γ-secretase activity was enriched also when an exogenous substrate was added to the reaction.
However, accumulating evidence suggests that identical or similar RAG mutations in relatives can lead to different clinical phenotypes12,25,26,27, indicating that mutations involved in V(D J recombinase activity are not solely responsible for the clinical outcome.
However, structure activity relationship demonstrates strict constraints to the structure of the inhibitors, and shows that activity is not solely correlated to Michael-addition suggesting a more complex mechanism of action.
However, estrogenic activity could not solely be attributed to E1 and E2.
This binding was initially proposed to divert Beclin 1 from interacting with and stimulating class III phosphatidylinositol-3-kinase Vps34 activity [19], but a consensus now argues against a mutually exclusive interactions of Beclin 1 with Bcl-2 and Vps34 [24]–[26], underlining that autophagic activity is not solely driven by Beclin 1 association with Bcl-2/Bcl-xL.
For an ATP-dependent kinase such as IP6K (inositol hexakisphosphate kinase) or PPIP5K, its activity may not solely depend upon the concentrations of inositol phosphate substrates.
The weak correlation shows that MS/DB neuronal activity is not solely involved in olfactory processing but rather integrates processed respiratory signals.
We observed a significantly milder effect with mis-expression of Robo1, suggesting that Robo2's non-cell autonomous activity is not solely a consequence of Slit titration.
Similarly, total soluble activity is not solely responsible for determining starch content, because the Atss2, Atss3 double mutant is deficient in starch even though the remaining SS classes are able to provide a high level of activity.
Since all these antibiotics target the ribosome, it is also possible that the increased resistance is due to a decrease in translational activity, and not solely because of the expression of resistance genes.
