In addition to reducing COX-2 activity and increasing tyrosinase activity, we hypothesized the α-MSH-induced PPAR γ increase contributed to the activities of antioxidant(s).
Based on the recent report suggesting that thionein in addition to Trx could serve to activate MsrA activity, we hypothesized that TXNL6 might act as a reducing system for MsrA repair of the essential lens proteins α-crystallin/sHSP and cyt c.
Because PCAF was one of the genes significantly regulated by APC upon inflammatory stimulus and has acetyltransferase activity, we hypothesized that APC might regulate activity of HATs.
The helicase activity was hypothesized to be the recombinagenic activity of the enzyme, unwinding the DNA and creating single-stranded DNA ends of both polarities that are coated with RecA and capable of invading a homologous duplex DNA molecule.
Because the MTT assay is largely based on mithocondrial LDH activity, we hypothesized that Rottlerin could enhance LDH activity indirectly, by maintaining high levels of NADH, due to its H+ donor properties.
Knowing that LAP in vitro limits TGF-β1 activity, we hypothesized that TGF-β1 functioned similarly toward LAP activity.
Having shown that the proximal and distal cell populations are both affected by increased β-catenin activity and the proximal is affected by decreased β-catenin activity, we hypothesized that the different levels of β-catenin signalling within the gradient specify the positions of identities in the nephron.
Based upon this strong activity, we hypothesized that neuroblastoma/monocyte suppression of NK cell activation could be overcome by lenalidomide.
Since cardiac MuRF2−/− mice exhibited enhanced PPAR activity, we hypothesized that the induction of diabetic cardiomyopathy would result in both enhanced PPAR activity, resulting in significant cardiac dysfunction compared with wildtype mice.
As other delivery techniques based on intracellular nuclease production may lead to prolonged nuclease activity, we hypothesized that ZFNs delivered in LPs would have low off-target relative to on-target activity.
