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The most common mutation K-Ras(G12V), required for tumor proliferation, survival, and metastasis due to its constitutively active GTPase activity, has provided an ideal target for cancer therapy.
Exceptions include Zaire Fan, where recent activity has provided useful insights into flow processes.
The finding that Aβ has antimicrobial activity has provided evidence to suggest that microbial infections induce the formation of Aβ-containing senile plaques10.
The chairman publicly assured his manager on Thursday that "substantial" funds were available but the Dane believes a lack of activity has provided a void for claims of unrest to develop.
This activity has provided a greater understanding of the basic biology of the target, answering many questions about the potential therapeutic roles for histamine H3 receptor ligands and also raising some more fundamental questions about the nature of the receptor system.
In vitro reconstitution of γ-secretase activity has provided initial insights into the enzymatic mechanism.
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Host defense peptides that exhibit potent, broad spectrum antimicrobial activity have provided the basis for significant research into the development of novel antimicrobial agents, including antifungals.
Bisphosphonates and RANK/RANKL inhibitors, which inhibit osteoclast activity, have provided a degree of success by slowing osteolysis; however, many patients with breast cancer are incapable of repairing the bone matrices that have been resorbed [8], [9].
In summary, the discovery of Nutlins as potent MDM2 antagonists with in vitro an in vivo activity have provided compelling evidence that the p53 MDM2 interaction represents a tractable target for pharmacological intervention.
Experimental correlations between molecular pMHC TCR binding kinetics, typically determined from solution assays of soluble extracellular domains and bulk measurements of T cell activity, have provided the foundation for much of this understanding.
The organization's explanation for such technological quirks — some applicants have found that the form also cuts off parts of parents' job titles, as well as details of their own extracurricular activities — has provided little comfort.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com