Recent nuclear magnetic resonance (NMR) studies of pol β(E295K) demonstrate the failure of a correctly matched ternary complex to induce the conformationally activated state, a result consistent with the extremely low activity found for this mutant.
However, the docking scoring functions used probably overestimated the weight of electrostatic interactions between the ligands and key active-site residues in the protein environment, which may account for the modest activity found for the designed inhibitors.
Figure 5 provides a representation of the bactericidal activity found for each STMC in E. coli.
In more walkable cities, activity is greater throughout the day and throughout the week, across age, gender, and body mass index (BMI) groups, with the greatest increases in activity found for females.
The calculated activation energies are of the order of magnitude of those obtained experimentally, explaining the higher activity found for the unbridged catalytic complex compared to the bridged.
The low cellulolytic activity found for bacterial species belonging to species of Microbacterium, Stenotrophomonas and Enterococcus genera suggest primary roles other than carbohydrate degradation in the larval intestine.
