Compounds 12a, 12d, and 28 are the most active derivatives in this series, displaying activity comparable to that of retapamulin and BC-3781.
Three cationic alpha helical peptides exhibited antimicrobial activity comparable to, or even better than the comparator omiganan (MBI-226).
Tissues from RIαB mice expressed PKA activity comparable to WT mice, suggesting that one active RIα allele is sufficient to maintain PKA activity in most situations (Figure 3A).
Some of them even show an activity comparable to noble metals [10, 11].
"Exploring is a very physical activity, comparable to back-packing," he says.
Compounds 34, 56 and 66 showed broad spectrum antimicrobial activity comparable to Gentamicin and Ciprofloxacin.
PPh2CH2-Cp exhibited an antibacterial activity comparable to that of the original drug.
The compound 10f demonstrated high antimicrobial activity, comparable to that of linezolid against Staphylococcus aureus.
Results indicated that most of the tested compounds showed moderate to good activity comparable to indomethacin.
Compound 18 showed broad-spectrum antimicrobial activity comparable to the known antibiotic gentamicin.
All the compounds showed activity comparable to that of the standard drug, ciprofloxacin.
