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TCS did not exhibit estrogenic activity at any concentration shown in the absence of E2.
However, fluoxetine showed no significant effect on EAAT3 activity at any concentration tested (Fig. 3).
It should be noted that elaidic acid (18 1 trans), the isomer of oleic acid, did not change the PHLPP activity at any concentration tested (data not shown).
Similar(57)
Therefore some additional mechanisms may act to elevate the PPP activities at any concentration of d-glucose.
Despite many of them not demonstrating any inhibitory activity at a concentration of 200 µg/ml, it was pleasing to see that the bromoacetamido analogues that were prepared to facilitate an SN2 type substitution between the ligand and the Cys112 residue, were active.
The benzophenone exhibited no estrogenic activity at any tested concentration.
Neither Mirtazapine nor Mianserin showed a DPPH‐scavenging activity at any relevant concentration.
Because fluoxetine did not show any significant effect on EAAT3 activity at any tested concentration, we excluded it from this study.
Imidazole did not lead to any inhibition of PepP activity at a concentration of up to 10 mM.
However, no compounds showed obvious activity at a concentration of 40 μM.
All the compounds were able to inhibit FGFR3 kinase activity at a concentration of 50 μM.
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