These categories include peptidase activity, photoreceptor activity, signal-sequence binding, oxidoreductase activities, transferase activity, heat shock protein binding, ubiquitin conjugating enzyme activity, unfolded protein binding, ATPase activities, SNAP receptor activity and ligase activity.
Moreover, these lincRNAs might modulate the effects of multiple molecular functions, including binding, structural molecular activity, transporter activity, catalytic activity, and electron carrier activity, and they may exhibit translation elongation factor activity, unfolded protein binding activity, monooxygenase activity, ammonia-lyase activity and GTPase activity (Additional file 18).
Ubiquitin conjugating enzyme activity and unfolded protein binding were especially prominent molecular function GO categories, which were significantly enriched according to all three terms of the two-way ANOVA.
Brunsing, R. et al. B- and T-cell development both involve activity of the unfolded protein response pathway.
The process of assisting in the restoration of the biological activity of an unfolded or misfolded protein, which is dependent on additional protein cofactors.
In summary, our data provide further evidence for the potential catalytic activity of natively unfolded proteins, and provide the basis for engineering of alphavirus capsid proteins towards hydrolytic enzymes with novel specificities.
A parallel, cellular homeostatic pathway with antiviral activity is the unfolded protein response (UPR), or endoplasmic reticulum (ER -stress rER -stressthway.
Activity of the unfolded protein response (UPR) is unaffected by depletion of ER glutathione.
This prevents the catalytic domain, which is responsible for catalytic activity, from being unfolded and dysfunction due to changes in the structural stability and configuration.
Here we considered the possible implication of the EGFR ligand epiregulin (EREG) in glioma development in relation to the activity of the unfolded protein response (UPR) sensor IRE1α.
