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Whether the ancestral polypeptide possessed both activities remains unknown; however, ancestral protein reconstruction could shed light on this issue.
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The conservation of the complete set of catalytic residues typical of Palm domain polymerases and cyclases implies that the Palm domain of Cas10 is enzymatically active but the nature of this activity remains unknown.
Why some patients suffer from high CSF viral loads and/or signs of intrathecal immune activation while others exhibit only minor signs of CNS infectious activity remains unknown.
But whether it revives economic activity remains unknown.
The etiology of physiologic bowel 18F-FDG activity remains unknown.
The extent to which such strategies can improve adherence to physical activity remains unknown.
Though Cav2.3 is also expressed in key structures of the thalamocortical circuitry, their functional relevance in non-convulsive absence seizure activity remains unknown.
It is possible that Shulgin chose not to ingest MDMM4 due to its structural similarity to the endogenous neurotoxin salsolinol and so its activity remains unknown. .
While an immunostimulatory role in the generation of cytotoxic T lymphocytes was observed, their exact contribution to this antiviral activity remains unknown [31].
This enzyme plays a role in the ER-associated degradation (ERAD) pathway in yeast and mice, but the biological importance of this activity remains unknown.
Although the precise mechanism of ibudilast's action on NF-κB transcriptional activity remains unknown, we concluded that ibudilast may block NF-κB activity in a manner that is independent of nuclear translocation and phosphorylation of RelA.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com