Artemis is an SNM1-like exonuclease that, upon complex formation with DNA PKcs, acquires endonucleolytic activity capable of processing complex DSBs, including the DSBs that occur in lymphocytes during V(D J recombination (Pannicke et al. 2004).
Its extracellular domain encodes a membrane-associated dipeptidyl peptidase IV (DPPIV) activity capable of processing amino-terminal dipeptides from polypeptides with either L-proline or L-alanine in the penultimate position (Oravecz et al, 1997).
An important future challenge is the determination of the signaling pathways which modulate the activity of miRNA processing accessory factors such as KSRP and hnRNPs.
Nevertheless, both activities of 3'end processing and strand transfer are highly impaired in the double mutant.
Finally, methylation status and activities of miRNAs processing molecules were also studied in those samples.
DM is unusual because it is an RNA-mediated disorder due to the expression of toxic microsatellite expansion RNAs that alter the activities of RNA processing factors, including the muscleblind-like (MBNL) proteins.
The proposed method accumulates the flow estimates in a video, and extracts "regions of activity" by processing their higher-order statistics.
In short, the anticipatory fronto-parietal activity is not only predictive of subsequent VSTM performance but also of subsequent levels of sensory activity when processing the memoranda.
Since the activity of prohormone processing enzymes is essential for the production of (most) bioactive peptides, the neuropeptidergic regulation of (many) physiological processes may also be indirectly linked to the level of precursor processing.
The catalytic activity of Dicer processing of some miRNAs is increased by removal of the amino-terminal helicase domain, indicating that this domain may serve an autoinhibitory function [ 184].
