This meant that all strategy components were neatly divided into activities, objectives, and outcomes.
Physical activity Objective physical activity will be assessed using triaxial accelerometers (Model: Actigraph GTX3+).
Antitumour activity Objective tumour response was evaluated at week 8 and week 12.
The combination showed a very high rate of activity (objective response rate 68%), and a favourable toxicity profile.
Mediating factors that reflect circadian rhythmicity will include diurnal HPA axis activity, objective accelerometer measures of sleep duration and subjective measures of sleep duration and quality.
In addition, studies have shown that students are engaged in moderate-to-vigorous physical activity (objective measurements of MVPA) for only 20-47% of the physical education class time [ 31- 33].
A recent pilot trial found that continuous, low-dose GM-CSF had substantial activity (objective response rate 37%) in heavily pretreated patients with either metastatic breast cancer or female genital tract cancer (Kurbacher et al, 2005).
Study strengths include the long follow-up time, repeated assessment of the occupational physical activity, objective measures of several covariates from clinical examinations, information on outcomes obtained from valid registers, and participation of both sexes.
It is likely that the ability of these electronically self-monitored subjective measures may not be sufficient to detect prodromal depressive and manic symptoms compared to automatically generated behavioural data on measures of illness activity (objective measures) such as phone usage, social activity, physical activity, and mobility.
