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Furthermore, quercetin markedly restored Cu/Zn-SOD, CAT and GPx activities in the kidney of lead-treated rat.
Catalase activities in the kidney of aged rats were also reduced by hot environments.
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These results support the view that de novo ceramide production is involved in Hcys-induced NAD(P H oxidase activity in the kidney of hHcys rats and indicate the important role of ceramide-mediated redox signaling in hHcys-induced glomerular injury in rats.
Systemic infusion of Ang-(1 7) for 5 days increased NF-κB DNA-binding activity in the kidney of wild-type mice (Mas+/+ and TWT) (Figure 4C) and stimulated release of proinflammatory cytokines (data not shown).
Because introduction of the HA-tag could have altered protein function, we evaluated ADA activity in the kidney of transgenic mice from line 2 (ADAtg).
It supports the fact that Vitamin E supplementation increased non enzymatic antioxidants activity in the kidney of rats submitted to exercise stress.
Taken together, our data indicate that increased mTORC1 activity in the kidney of compound Pml−/− Tsc2+/− mice does not modify the incidence of cysts and small carcinomas but accelerates tumour progression, as measured by several parameters that correlate with aggressiveness in human kidney tumours.
Alternatively, an increased renal production of Se- proteins such as GPx could limit the loss of Se, which is supported by the fact that we indeed observed increased GPx activity in the kidneys of TRα1+m mutant mice.
We also observed upregulation of c-Src activity in the kidneys of db/db mice and STZ-induced diabetic rats.
In order to confirm assay specificity, we compared ACE2 activity in the kidneys of ACE2 wildtype (ACE2+/+) and knockout (ACE2-/) mice [ 18].
Having demonstrated increased NO activity in the kidneys of diabetic Ren-2 rats we next went on to examine whether these animals were protected from the deleterious effects of VEGFR-2 inhibition with vandetanib.
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