In contrast, the relation between endocrine activity deficiencies and certain age-associated diseases like the andropause (lack of testosterone) has found its way into clinical studies.
Acquired thrombotic thrombocytopenic purpura (TTP) in adults, an element of the TMA syndromes, is caused by a severe ADAMTS13 activity deficiency chiefly through anti-ADAMTS13 auto-antibodies.
Furthermore, a feedback resistant lysC from Corynebacterium glutamicum encoding the aspartate kinase was introduced to complement the enzymatic activity deficiency caused by thrA deletion and a 9% increase of ectoine titer was obtained.
There was also no apparent activity deficiency in 8-m-old uko/3cv mice (Video S1).
However, in females, when G6PD deficiency was defined by enzyme activity, deficiency was associated with a 52% reduced risk of uncomplicated malaria.
Galactocerebrosidase (GALC) enzyme activity deficiency is observed in almost all cases of Krabbe disease [ 9].
APE1H309N, APE1C65S and APE1K6R/K7R represent repair activity deficiency, redox activity deficiency, and acetylation site mutants that were separately transfected into APE1 at 24 hours post shAPE1 adenovirus infection in RPMI-8226/LR5 cells.
It is difficult for type I RIPs to enter cells because of their sugar-binding activity deficiency.
For three genes annotated to have methyltransferase activity, deficiency of CG10903, but not Mt2 and CG9666, affected viability (Table 1).
Yeast mutants with total or partial FECH activity deficiency and resultant protoporphyrin accumulation have been isolated [ 63].
Moreover, the multivariate analysis demonstrated that the increase of lipid peroxidation was negatively correlated with GPx activity deficiency, demonstrating that ROS generation can contribute to decreased GPx activity.
