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Using two highly conserved human antigens (MIF and HMGB1) and one mouse self-antigen (TNF-alpha) as examples, we demonstrate here that multiple clones of high affinity, highly specific antibodies with desired biological activities can be generated, using the NZB/W mouse as the immunization host and a T cell-specific tag fused to a recombinant antigen to stimulate the immune system.
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Further, diverse mimotopes of active virus antigens that can mimic the JEV neutralizing antigen activity can be generated.
Native tissues, such as cartilage and bone, exhibit piezoelectric behavior, wherein electrical activity can be generated due to mechanical deformation.
A hazard-zone map for landslides triggered by regional seismic activity can be generated rapidly based on a comprehensive index method.
Thus, a large number of neurons can be tested for their relationship with behavior and detailed spatial maps of behavior related neuronal activity can be generated as exemplified here with recordings from lick-related Purkinje cells in the cerebellum.
A more fundamental difference in the model of Grossberg and colleagues is that they use additive feedback connections with the effect that new activity can be generated in model area V1 at positions where initial bottom-up signals are zero.
Indeed, it has been proposed that self-sustaining, time-varying neural activity can be generated by the internal dynamics of recurrently connected networks.
In summary, this study provides proof of concept that good-quality, fully human mAbs with desired specificity and biological activity can be generated with the SEQUENTIAL method.
Independent coding offers a massively increased ability to encode multiple environments, while coordinated coding provides a mechanism by which robust sequential activity can be generated despite the noisy intrinsic properties of individual place cells.
This model reproduces how different activity patterns can be generated from a given daily individual activity list.
(delta_{text{I}}) determines the distance between which a fictitious activity duration can be generated around its nominal duration.
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