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Nrf2-promoter activities were validated utilizing ARE-luciferase assays, where UroA/UAS03 significantly enhanced luminescence upon treatment (Supplementary Fig. 9b) similar to known Nrf2 activator sulforaphane (SFN) albeit at lower levels.
For a specific cancer type, users can retrieve the list of natural products and fractional extracts whose anticancer activities were validated with varying cancer cell lines.
At NPCARE, one can explore 6578 natural compounds and 2566 fractional extracts isolated from 1952 distinct biological species including plants, marine organisms, fungi, and bacteria whose anticancer activities were validated with 1107 cell lines for 34 cancer types.
Moreover, inhibition of GAK activity was validated as an important mechanism of antiviral action of these compounds.
The interest for this original tricyclic heteroaromatic scaffold as modulators of CLK1/DYRK1A activity was validated by nanomolar potencies (compounds 12 and 13).
This activity was validated in hepatocellular tumors induced in nm23-1 deficient mice.
Among the 10 weak-agonists is the pMHC from the PDB structure 2ol3, whose lower propensity to elucidate T cell activity was validated by the low level of cytotoxicity observed from cytotoxicity assays by Mazza et al. [28].
The results of antimicrobial activity were validated when compared to the controls.
Role of PAK1 as a mediator of mesalamine activity was validated in vitro and in vivo.
FVIIa activity was validated by measuring TF/FVIIa specific upregulation of IL8 mRNA in MDA-MB-231 cells [ 16].
In this manner, the results from a cohort with, on average, moderate disease activity were validated in another one with high disease activity (Table 1).
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com