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Furthermore, the kinase activities are required for IFN-β-promoter activation, suggesting that TBK1/IKK-i activates IFN-β promoter by phosphorylating one or more appropriate substrates.
Importantly, both activities are required for optimal transcription activation on a chromatin template in vitro and on an endogenous MLL1 target gene, Hox a9, in vivo.
This physical association between enzymes removing the H3K27me3 repressive mark, on the one hand, with protein complexes promoting the deposition of the active H3K4me3 mark, on the other hand, suggests that both activities are required for a rapid and stringent response of target genes.
These activities are required for recruitment of splicing factors to the site of active transcription and stimulation of co-transcriptional splicing [12] [15].
Given that several catalytic activities are required for plant polysaccharide degradation and dissolution, screening of carbohydrate active enzymes (CAZymes) by ToF-SIMS could be achieved by augmenting the activity of a known cellulase cocktail [ 1].
FAK and myosin-II activities are required for durotaxis in PSCs.
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Therefore, HPK1 kinase activities were required for the loss of HPK1 protein in PDAs.
PARP1 and its poly(ADP-ribosyl)ation activity are required for maintaining FOS activation kinetics.
Studies of drug inhibitors indicate actin polymerization and phospholipid kinase activity are required for HCV replication.
Together these findings suggest that Rac1 and myosin-II activity are required for ICAM-1 dynamics.
10.7554/eLife.06547.020 Figure 3. ESCRT-III binding and kinase activity are required for ULK3 function.
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