Exact(5)
Therefore, the present work aims at designing targeted liposomes containing nucleic acids, with small size, high encapsulation efficiency and able to be actively internalized by SCLC cells, using a hexapeptide (antagonist G) as a targeting ligand.
The resultant nanoparticles were 39.4 nm in size and actively internalized by cancer cells.
At acidic pH, amino-PEG coated QRs, showing positive surface charge, are actively internalized by tentacle and body ectodermal cells, while negatively charged nanoparticles are not uptaken.
During hyphal growth and appressorium formation, endocytic markers were actively internalized by both conidia and conidial germlings on rice leaf, suggesting that endocytosis might play a significant role in spore germination and growth of the germ tube [44].
As is expected for cells treated with agents that are actively internalized by the cell a number of deletion strains of proteins involved in endocytosis exhibited sensitivity to NiSO4 (Fth1, Rvs161, Cup5, Ypk1, Whi2) (Table 1).
Similar(55)
Use of AMF/PGI as a carrier of a chemotherapeutic drug represents a novel therapeutic approach unique in that, firstly, it utilizes a native circulating protein that should not elicit an immune response and, secondly, it targets a receptor that is over-expressed and actively internalized via a distinct endocytic pathway by specific cancers.
This may be because Notch is already actively internalized; increasing the Awd level cannot further enhance such activity.
The protein actively internalized into the cells and showed superior protection against oxidative stress-induced cell death over native enzymes fused with TAT.
Moreover, they were actively internalized at a temperature of 37°C but restricted to the cell membrane at 4°C.
This formula determines the amount of HER-GP and HER-GLPs that is actively internalized.
CA IX is also actively internalized in the endocytic pathways, the latter being a route for CA IX redistribution in intracellular compartments, including perinuclear regions and nuclei.
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