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Whether the activation of Bax and Bak occurs only indirectly is, however, actively debated.
The clinical relevance of iron excess in these disorders, in terms of fibrosis development and cancer risk, is actively debated, but increasing data indicate that iron may sustain disease activity and/or contribute to its progression.
Disruption of tumor suppressor genes (by insertional mutagenesis) and inappropriate activation of positive effectors (by epigenetic dysregulation) are obvious mechanisms that could promote tumorigenesis, however, the extent to which activation of retrotransposition contributes to the total human cancer burden is currently actively debated [ 49].
Plot points were still being actively debated.
It was actively debated in the House of Commons and, of course, the consensus was no.
On the Internet, which has made such things documentable, interpretations have been actively debated since at least 1993.
Thirty years ago, when there were around two and a half billion fewer human beings on the planet, the idea was actively debated.
Whether this shift is merely tactical, and related to the peace process,or of longer-term strategic significance, is actively debated.
These are just some of the ideas that could provide a way forward, but few have been actively debated in Paris these days.
Gay marriage has recently been legalized in South Africa, Canada and many European nations, and is being actively debated in others.
American support could also change the tone of the next Arab League summit meeting, scheduled for March 27 in Beirut, Lebanon, when the Saudi proposal is likely to be actively debated.
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CEO of Professional Science Editing for Scientists @ prosciediting.com