This is certainly incorrect because, as described above, mutations in EGFR that cause it to be constitutively active are well known to lead to the constitutive activation of ERK and to the subsequent development of cancer.
He was active and well known in his local community in Reading, where he served as a governor at Maiden Erlegh secondary school.
A prominent lawyer in Indiana, he became an active and well known member of the Indiana Democratic Party by stumping across the state for other candidates and organizing party rallies that later helped him win election as the 27th Governor of Indiana.
The magnetorheological properties of ferrofluids (or smart, or active fluids) are well known, and are currently exploited in shear in advanced damping systems in the automotive industry, robotics (prosthesis), and machine tools (chatter reduction, positioning).
The health benefits of an active pregnancy are well known.
This study was the first to associate diabetes with increased TB mortality (HR = 1.89), although the relationship with active TB was well known[ 35].
At the time of communicating this review article, there were altogether 24 such active, open source, well known and broadly used human cell signaling databases available, which fulfill these two criteria.
During the inflammatory process in arthritis, the immune and inflammatory responses are active, and it is well known that an imbalance between pro- and anti-inflammatory cytokine activities favors the induction of autoimmunity, chronic inflammation and thereby joint damage [ 13].
The Bose Quiet Comfort line is probably the most well known active noise canceling headphone on the market.
Swelling and shrinkage of electrochemically active conducting polymers is well known and may lead to degradation of the electrode during cycling.
In this study, well known active and passive methods were modified for the evaluation of the health of the riveted joints between the plates.
