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Among in-ICU died patients, 46 pts had a limitation of active therapeutics after 24 h (17.5 %).
Non-inclusion criteria were: hemopathy, cancer diagnosed during ICU stay, cancer remission superior than 5 years, limitation of active therapeutics and ICU stay inferior to 24 h.
Antibody technology has transformed drug development, providing robust approaches to producing highly targeted and active therapeutics that can routinely be advanced through clinical evaluation and registration.
Design criteria were established for the hydrogel to be — injectable, fast-gelling, biocompatible, biodegradable and able to release biologically active therapeutics when injected into the intrathecal space that surrounds the spinal cord.
Data concerning cancer (type of cancer, number of metastasis, number of chemotherapy lines), reasons for admission (classified as related to cancer progression, related to complications of chemotherapy and other), patients (age, severity at admission, need of life-supporting therapies, decision of limitation of active therapeutics after 24 h) and outcome were collected.
One of the major issues for the use of nucleic acids as active therapeutics for a broad range of cancers, infectious disease and other disorders is the safe and successful targeted delivery to specific organs upon systemic administration.
Similar(53)
Assuming that all diseases have in common the perturbation of cellular redox environment, developing SOD mimics still seems to be the appropriate strategy for the design of potent redox-active therapeutics.
Oncolytic viruses carry great potential as broadly active cancer therapeutics, as they simultaneously interfere with multiple cell survival signaling pathways and trigger inflammatory responses, which, in turn, may expose the tumors to the immune system.
G protein-coupled receptors (GPCRs) are therapeutic targets for many diseases, but progress in developing active and selective therapeutics has been severely hampered by the difficulty in obtaining accurate structures.
However, it has often been neglected, which needs to be considered for its active role in therapeutics or otherwise.
Antibody-maytansinoid conjugates (AMCs) have emerged as one of the most promising active targeting cancer therapeutics.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com