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Based on structure activity relationships, we proposed that these compounds adopted active structures for κ selective agonist activity.
However, the micro- and nano-structural properties of those mechanically active structures contain valuable information on the route from outside mechanical signals to inside biochemical regulation.
Compounds with shared basic active structures (BASs) exhibiting G-protein coupled receptor (GPCR) activity and repeated dose toxicity have been mined from small datasets.
Among the concurrently active structures, that with the highest weighting gains awareness and is most directly responded to.
We call these substructures "basic active structures" or BASs.
The final data sets were used as active structures.
The harmonic weighting scheme uses weights representing the ranks of the active structures within each cluster.
The concept of basic active structures (BASs) has been discussed previously [1].
We obtained the modified active structures of Good and Oprea from the DUD site [38].
The hypocenter distribution indicates a complex net of seismically active structures.
The results provide a more detailed understanding of active structures compared to previous studies [2, 13].
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