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The phrase "active role in setting up" is correct and usable in written English.
It can be used when discussing someone's involvement or participation in establishing or organizing something, such as a project, event, or system.
Example: "She took an active role in setting up the new community center, ensuring everything was in place for the grand opening."
Alternatives: "key involvement in establishing" or "significant participation in organizing".
Exact(3)
The BBC's Karishma Vaswani in Jakarta quoted police as saying that Mr Ba'asyir played an active role in setting up the camp, appointing key people and receiving reports from extremists in the field.
In the process of establishing the Leleshwa Camp, Joe got to know the local Maasai community and took on an active role in setting up the Siana Conservation Area.
Despite these limitations, the ward councilor and other stakeholders were found to have played an active role in setting up and supporting the Eden programme: … we use the ward committee to communicate with the community.
Similar(57)
Under State Street's IT governance structure, the CIO plays an active role in setting the company's IT strategy and facilitating the effective use of IT.
Senator DeConcini took the lead role in setting up the meeting.
It is not the case that Mr. Corbyn played a role in setting up the group.
He plays a key role in setting up for lectures, classes, student presentations, and even setting up easels for poster sessions.
Today, Vinson denies having any direct role in setting up or running the clinic.
The Schwartz family has had no role in setting up or managing the two charities.
Astrocytes play a powerful role in setting up the basic scaffolding of the brain during development.
"Hydrogen might play a role in setting up bad [infections]," he says.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com