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The data suggest that biomaterial matrices incorporating denatured collagen may promote more active remodeling toward new extracellular matrices in comparison to cells grown on non-denatured collagen.
Once in circulation, EPCs home in on activated tissues in response to chemokine gradients that are formed in the tissue regions undergoing active remodeling.
To accommodate this observation in the setting of an osteo-anabolic effect on bone, we hypothesized that repeated teriparatide administration reduces the active remodeling surface as old bone becomes a progressively smaller component of the total bone surface.
Remarkably, the presence of subchondral bone attrition in knee OA, defined as flattening or depression of the osseous articular surface, is strongly associated with subchondral bone marrow lesions (BMLs) on MRI, In turn, BMLs reflect the presence of active remodeling processes due to chronic overload [ 23].
Consistent with active remodeling, increased MMP activity, particularly of MMP2 and MMP9, has been associated with ruptured Achilles tendon [ 26].
This molecular response entails initial perception of alterations, activation of signaling networks and effectors and suggests active remodeling of cytoskeletal proteins during the initial acclimation process.
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In one autopsy study, active remodelling of the artery was seen many years after the acute disease in children with aneurysms [5].
There appeared to be high levels of expression in both the frontoparietal bone and surrounding cartilage during the times of the most active remodelling as evidenced by the peaks in the graphs.
Cancer cell migration and invasion depend on an active remodelling of the actin cytoskeleton.
A previous histological study of CCF bones from adult CKCS has found evidence of active remodelling of the supraoccipital bone, with replacement of bone with cartilage [ 19].
This is supported by the previous finding that a large part of the supraoccipital bone of adult CKCS is cartilage, suggesting active remodelling [ 19].
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