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That it's dead serious, and a kind of preparation, and an active pathology that I prefer not to indulge.
Additionally, the available CT component with high-resolution capabilities can provide additional diagnostic clarity of the metabolically active pathology and may detect additional, non-active pathologies.
Controls had no evidence of active pathology (table 1).
Four main factors lead to disablement: active pathology, physical impairment, functional limitation, and disability.
The conceptual structure of disablement was adapted for OI in a model where active pathology was represented by a structural defect in collagen production or conformation, leading to impairments (skeletal disproportion and joint dysfunction), which, in turn, produce a functional limitation that leads to disability (makes the individual dependent on caregiver assistance) [ 7, 8].
The conclusion from these findings was that the rheumatoid bone marrow is a site of active pathology with a histology similar to that found within synovial membrane but with the addition of osteoclasts closely apposed to trabecular bone and likely to be mediating the erosive process.
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Four faculty pathologists (TY, SN, KT and SK) practicing in an active lymphoma pathology service who had varying degrees of experience in lymphoma pathology reviewed the records.
The exclusion criteria were recent contact lens wear (rigid contact lens within four weeks and soft contact lens within two weeks), any active ocular pathology, history of ocular surgery and trauma, intraocular pressure >21 mmHg, fundus disease and systemic diseases with ocular symptoms.
Three-phase bone scans, based on technetium-99m (99mTc), are highly sensitive for active bone pathology.
According to the conceptual model for the disablement process proposed by Nagi, 24 active organ pathology or disease leads to anatomical and physiological loss or abnormalities, which in turn lead to functional limitations resulting in disability.
Common exclusion criteria for PDS/PG were a history of ocular surgery or traumas, any active ocular pathology different from glaucoma, PEXS or PEXG, other causes of secondary glaucoma or a history of long-term use of topical or systemic steroids.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com