Sentence examples for active orientations from inspiring English sources

Recently, single-molecule analyses using either the isolated dimer of VFT domains or the full-length mGlu2 receptor dimer have confirmed that the VFT domains oscillate rapidly between the resting and active orientations (Olofsson et al. 2014; Vafabakhsh et al. 2015).

In order to test whether this implication holds true, we employed a system we previously used to determine the active orientations of the transmembrane and cytosolic domains of the Epo receptor [34].

We identify one dimeric TM conformation that imparts full activity to the cytosolic domain of the receptor and signals via JAK2, STAT proteins, and MAP kinase, one partially active orientation that preferentially activates MAP kinase, and one conformation corresponding to the inactive receptor.

The dimer of VFT domains is in equilibrium between a resting and an active orientation, and agonist binding displaces the equilibrium towards the active state (Fig. 2).

Consequently, helix αC is "pulled in" to maintain the active orientation, and the usual pre-existing hydrophobic back pocket of the ATP-binding site is abolished.

Moreover, the new design gives the possibility for simple introduction of additional functional modules such as: sensorized modules for non-geometrical orientation of parts, or active orientation modules for improving efficiency of the system.

Benware [ 28] suggests when we learn to teach, we learn with a more active orientation.

More specifically, patients with a higher degree of active orientation are more likely to comply with treatment recommendations for BP [ 18], diabetes and physical activity [ 23].

Goal orientation was defined as the active orientation towards long-term goals coupled with a reliance on one's own actions and feelings of personal responsibility to obtain these goals.

The hypothesis pursued in the present study has been that bone formation by AMOR is attributable to the ability of anti-BMP-2 mAbs to capture and tether endogenous BMP-2 in a biologically active orientation.

Moreover, their apparent simplicity and transparency may also serve to provide a sense of control and empowerment, enabling cancer survivors to challenge medical decision making and generating an active orientation to the future.