As the sign-test limits the effect of possible outliers it is very robust in the sense that tracts will not be considered active on the basis of the FA signal behavior of a few voxels alone (See Figure 5).
Gemcitabine alone is active on the basis of an IndexSUM <300 in 42% of oesophagogastric tumours and 50% of colorectal tumours.
The results of the mutation analyses are listed in Table 2. Furthermore, we assessed whether TP53 missense mutants were transcriptionally active, on the basis of the IARC prediction models (http://p53.iarc.fr/MutationValidationCriteria.asp).asp
For libraries tested in individual assays, VCs predicted to be consistently active on the basis of multiple NBHs provide preferred candidates for target/assay-dependent library expansion and focusing.
The Benish et al. (2008) meta-analysis excluded groups of treatments because they were judged to be non-active on the basis of Wampold et al.'s (1997) criteria.
That is, although all the recruited patients with rheumatoid arthritis had an inadequate response or intolerance to at least one DMARDs and had active disease on the basis of the ACR 1987 revised criteria, a significant improvement in physical functions and a significant reduction in the signs and symptoms of the disease were seen in tofacitinib treated patients.
In the field of hydrotreating (HDT) catalysis, density functional theory (DFT) calculations are of great help to explore new active phases on the basis of volcano curve relationships correlating HDT activities and the sulfur metal (S M) bond energy chemical descriptor, calculated in transition metal sulfides catalysts.
Importantly, although Mes was observed in the active site following crystallization, this buffer molecule neither affects the specific activity of 20S nor the affinity of compound 1 for the active site on the basis of Ki value determination (F.J. Bruzzese, unpublished work).
The active formulation contained several cosmetic actives selected on the basis of their potential to address all major mechanisms generally recognized as being involved in the development of cellulite (see Introduction and Table 1 for more details).
In particular, the new adsorption models were used for the analysis of the microporous structure of two active carbons on the basis of nitrogen adsorption isotherms.
