Sentence examples for active nucleotide from inspiring English sources
In MTAP-positive cells, abundant adenine, generated from supplied MTA, competitively blocks the conversion of an analog, by adenine phosphoribosyltransferase (APRT), to its active nucleotide form.
Gemcitabine needs to be metabolised to the active nucleotide in order to radiosensitise the cells.
As a consequence of this, the active nucleotide forms of gemcitabine are effectively accumulated to high concentrations in the cell [ 5].
(A ) Anc-gkdup (circles) is an active nucleotide kinase in a coupled enzyme assay for the reaction shown; Anc-GK1PID (boxes) is inactive.
For numerical simulations, we used the intracellular half-life of each drug, if known; in the case of nucleosides, it is the cellular concentration of active nucleotide that is responsible for inhibition of viral reverse transcription.
The metabolic pathways by which 5-FU and the prodrug capecitabine are converted to active nucleotide analogues are well described (Thorn et al, 2011) and have led to a number of candidate gene-based pharmacogenetic studies.
Parasitic protozoa employ a salvage pathway to synthesize purines and generate essential active nucleotides, whereas mammals are capable of their de novo biosynthesis.
In an RNA-based protocell, active nucleotides, e.g. NTPs, would be abundant for the synthesis of RNA.
Using folate as a cofactor, the drug is converted to active nucleotides, such as fluorodeoxyuridine monophosphate, which inhibit the enzyme thymidylate synthase.
The apyrase and 5' nucleotidase proteins are known to facilitate the acquisition of a blood meal by removing pharmacologically active nucleotides that are important for platelet aggregation at the site of the injury [ 53].
However, this provides substantial evidence that the nucleoside analog can be delivered to solid tumors and implies that a wide spectrum of malignancies (pancreatic, breast, ovarian, small cell lung, non-small cell lung, bladder, and germ cell cancers) has the enzymes required to anabolize cytosine nucleoside analogs such as gemcitabine to active nucleotides.
