The phrase "active mutation" is correct and usable in written English.
It can be used in contexts related to genetics, biology, or any field discussing changes or adaptations that are currently occurring.
Example: "The researchers observed an active mutation in the gene sequence that could lead to significant changes in the organism's traits."
Alternatives: "ongoing mutation" or "current mutation".
If TTR-11 functions in axon regeneration upstream of CED-10, we would expect that a constitutively active mutation of the ced-10 gene would suppress the ttr-11 phenotype.
DNA fragments carrying the G12V or equivalent (constitutively active) mutation of human and Dictyostelium Rho GTPases were generated from wild-type cDNA by polymerase chain reaction-based site-directed mutagenesis.
It is well known that the EGFR E19/E21 mutation is a sensitive or active mutation to TKI therapy, whereas T790M and E545K are resistant mutations.
As well as becoming constitutively active, mutation can also result in overexpression of the protein because of alternative splicing of the last intron.
Although the frequency of EGFR active mutation in oral carcinomas is controversial (Hsieh et al, 2011; Mclntyre et al, 2012), MALT1 may negatively regulate the pathway by the suppression of gene expression regardless of the presence or absence of mutation.
We took advantage of a constitutively active mutation (V664E) in the TM region of the Neu receptor and compared the structures of the TM JM sequences of the wild-type and V664E mutant.
In the preclinical studies, avitinib as an irreversible EGFR inhibitor showed the unique features of the third-generation EGFR inhibitor reported by the Dana-Farber group with strong potent inhibitory activities against EGFR bearing both active mutations and T790M mutations, and a better selectivity between wild-type EGFR and mutant EGFR.
Two variants containing combinations of three (3-MUT: M74A, M141T, S174Q) or four (4-MUT: M74A, K86Q, M141T, S174Q) active mutations showed further reductions in activity.
Ligand-independent, constitutively active mutations of PDGFRα occur in about 5-8% of patients [ 7].
Functional analysis indicated that E203K, P124S and F53L were constitutively active mutations for MEK1 [ 78].
In a significant fraction of sporadic CRC lacking APC mutations, constitutively active mutations were found in β-catenin gene and removes target residues of this kinase.
