The phrase "active mustard" is not a standard expression in written English and may not be widely understood.
It could be used in a specific context, such as describing a type of mustard that is particularly flavorful or spicy, but clarity would depend on additional context.
Example: "For this recipe, I recommend using active mustard to enhance the flavor of the dish."
Alternatives: "spicy mustard" or "zesty mustard".
However, the 4-hydroxylation products of oxazaphosphorines are characterised by a rapid half-life and their spontaneously decomposed and tumourstatic active phosphoramide mustards show a low membrane permeability (Lenssen and Hohorst, 1979; Patterson and Murray, 2002).
For example, TRP Ankyrin 1 (TRPa1), a receptor that carries sensory information from the periphery, is coexpressed with TRPV1, activated by the active ingredient in mustard, allyl isothiocyanate (AITC), and TRP Melastatin 8 (TRPM8), involved in sensing cold temperatures, is activated by menthol extracted from mint leaves.
Like cyclophosphamide, IFO requires metabolic activation, mediated by cytochrome P450 enzymes (Walker et al, 1994), initially forming a 4-hydroxy metabolite, which spontaneously releases the active form – isophosphoramide mustard (IPM).
Cyclophosphamide itself is not cytotoxic but undergoes metabolic changes in the body predominantly in the liver with the formation of an active derivative, phosphoramide mustard [ 45], which is an alkylating agent capable of forming cross-links in DNA molecules and initiating apoptosis.
The active ingredient in pure mustard oil, AITC, activates TRPA1 and is involved in several functions (see cinnamon and garlic).
The first time a patient was treated with cyclophosphamide, the active part of nitrogen mustard, the tumour shrank – something not even thought possible at the time.
Ifosfamide mustard, an active metabolite of ifosfamide, was equally cytotoxic and showed similar mutagenic effects in SD1 and parental V79 cells.
To confirm this assumption in in vivo experiment, mice were injected with embichin (nitrogen mustard), another active alkylating agent with similar cytotoxic properties.
CPA is a pro-drug that is converted into the active cytotoxic alkylating phosphoramide mustard through the formation of 4-hydroxy-CPA 4-hydroxy-CPA 4-hydroxy-CPAaldophosphamide [ 16].
It is transformed in to active metabolites like aldophosphamide and phospharimide mustard in the liver, which then produces the wide variety of antitumour action.
