The phrase "active methylene" is correct and usable in written English.
It is typically used in chemistry to refer to a methylene group that is particularly reactive due to the presence of adjacent electronegative atoms or groups.
Example: "The reaction proceeded efficiently due to the presence of an active methylene compound, which facilitated the nucleophilic attack."
Alternatives: "reactive methylene" or "nucleophilic methylene."
The reaction may proceed by an initial Michael addition of the active methylene compound to the activated double bond of 1 followed by a tandem elimination of NHMe2 and condensation with ammonia to give compounds 7a,b.
Later on, the same group also synthesized a series of structurally diverse 4H-chromene derivatives (69) by the reactions of salisaldehydes (46), active methylene compounds (16,16a,18,67a) and C-H activated nucleophiles (28,55,57,68a,68b,68c,68d) employing the same nano-ZnO as catalyst in aqueous medium at 55 °C [125] (Scheme 9).
In this study, we synthesized a series of curcumin analogs by introducing the geminal dimethyl substituents on the active methylene group to find more potent Nrf2 activators and cytoprotectors against oxidative death.
From the proposed reaction mechanism, it was deduced that the cations of the ILs can form hydrogen bond with aldehyde to activate the CO bond as electrophile, and the anions of the ILs can promote active methylene compound to produce carboanion as nucleophile, showing dual function activation effect in the catalytic processes.
The behavior of thienopyrazole 14 toward active methylene reagents was also investigated.
This methodology was then generalized using other active methylene compounds, such as malononitrile.
Yet, when 4-chloro analogues IVa j and thiourea were heated [ 45] in absolute ethanol, the pyrrolopyrimidine-4 3H -thiones pyrrolopyrimidine-4 3H -thionesd in Scheme 2. Diazotisation reaction of amino groupyrrolopyrimidine-4 3H -thionesby coupling of the diazonium salt with actiVIa fthylenes (ex: malononitrile) has been reported [ 46– 48].
Aptamers were designed as the forward outer primer to trigger the LAMP reaction, and then the LAMP amplification products were combined with a redox active molecule methylene blue (MB) and analyzed by an electrode using differential pulse voltammograms (DPV).
The results of a comprehensive evaluation for properties of RWCC with the highly active polymeric methylene diphenyl isocyanate adhesive (PMDI) as binder system not only present excellent mechanical properties, but also possess some of functional properties such as optimized acoustic properties and energy conservation.
APR-246 is a prodrug that is converted to the active compound methylene quinuclidinone (MQ), a Michael acceptor that binds to cysteine residues in mutant p53 and restores its wild-type conformation.
The vertically aligned CNTs were shown to enter immune cells (macrophage cell line) naturally without application of any external force and sense the intracellular presence of a redox active moiety, methylene blue (MB).
