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Active lung infection is not required to develop airway narrowing.
(A) Multiple PET axial image slices from a rabbit with an active lung infection are shown for demonstration purpose (color code: cold).
Moreover, a more recent study from our group performed in an active lung model demonstrated that PAV+ delivered a lower mean Paw from the mean Paw which should delivered based on the equation of motion [53].
Using an active lung model with different respiratory mechanics, we compared (1) the actual delivered P aw by the ventilator to the theoretical P aw as defined by the equation of motion and (2) the WOB value displayed by the ventilator to the WOB measured from a Campbell diagram.
However, using a metabolically active lung model, Olegard et al. have nicely demonstrated that errors in RQ computation have a negligible effect on the precision of EELV measurements [1], suggesting that the high FiO2 used in our study may have only marginally influenced our results.
Exclusion criteria were as follows: patients undergoing invasive ventilation, patients with a primary diagnosis of right-sided heart failure, patients with active lung cancer, pulmonary fibrosis, interstitial lung disease, or pneumonia, patients who we are unable to have an ultrasound within the first 24 h of admission and patients who are not competent to sign the consent form.
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(B ) There was no difference in the proliferation index between CCO-deficient clonal patches and CCO-active lung epithelia.
(F ) There was no difference in lineage-specific differentiation between the CCO-deficient patches and the CCO-active lung epithelial cells.
(H ) There was no difference in lineage-specific differentiation between the CCO-deficient patches and the CCO-active lung epithelial cells.
On examination of the lower conducting airways, the frequency of Clara cells in CCO-active lung epithelial cells matched with that of the neighbouring tissue.
Based on the percentage of constituent cell types, we found that there was no significant difference in cell type composition between CCO-deficient clonal patches and the neighbouring CCO-active lung epithelial cells.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com