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Additionally, the 0.3 and 1.0 doses of varenicline non-specifically increased active lever responding during the reinstatement test sessions.
Food was dispensed when the "active lever" was pressed.
Each mouse was assigned either the left or right lever to the active lever, and the side of the active lever was counterbalanced between mice within each genotype.
Pressing the inactive lever caused a 15 sec inactivation of the active lever.
The speakers for tone generation were located immediately below the active lever.
Pressing the active lever produced an auditory tone coupled with the delivery of 1 food pellet.
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One observing lever press (Fig. 1c) illuminated the light above the currently-active lever for a pre-determined period (detailed below).
Presses on the observing lever that turned on the active-lever light.
In contrast the active/inactive lever discrimination was unaffected when the active-lever light was illuminated.
However, this behaviour was absent when active-lever light information was available.
High-checkers illuminated the active-lever light for approximately 21% of the session (264 ± 39 s), whereas low-checkers illuminated the active-lever light for approximately 5% of the session (65 ± 11 s).
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