The phrase "active in the observed" is not correct and lacks clarity in written English.
It may be intended to describe someone or something that is engaged or involved in a situation that is being observed, but the phrasing is awkward.
Example: "The researchers noted that the participants were active in the observed interactions during the study."
Alternatives: "engaged in the observation" or "involved in the observed activities".
Thus, Cdx binding may favor binding to a partially open state that destabilizes oxy-P450cin but is not sufficiently altered to give the large changes in the active site observed in the fully open P450cin structure.
The above considerations notwithstanding, the arrangement of residues in the active site as observed in the X-ray structure strongly suggests the core elements (four Cys side chains, Hg2+, and WAT) of the current model are correct.
Our study suggests that the positive socioeconomic gradient in active commuting observed in the European-Dutch may be less strong in the South Asian- and African-Surinamese ethnic groups.
In contrast, EGFR phosphorylation was barely detectable in HARA tumours, suggesting that the receptor was not active to the extent observed in the RWGT2 line.
This alteration of the active site is reflected in the changes observed in the kcat,app and Km,app values for the S182A, S186A, and S182A/S186A mutants.
Pirfenidone is an orally active, synthetic small molecule that inhibits the synthesis of transforming growth factor β and tumor necrosis factor-α, both of which have been demonstrated to play an active role in the fibrosis observed in IPF [ 12– 17].
A stronger offshore land breeze during the active MJO compared to before the onset of the active MJO was observed in the early morning (not shown) during the pre-YMC field campaign, which probably caused wind divergences in the lower troposphere, suppressing convection over the island.
At larva stage construct 2B is specifically active in the corresponding anterior territories observed at tailbud stage.
Importantly, Dpo4-catalyzed insertion of dCTP does not readily induce ring opening of M1dG to form N-OPdG based on the efficiency and fidelity measured in kinetic assays and the active site orientation observed in the crystal structure.
By contrast to the major rearrangements of loops surrounding the active site centre observed in the (E192Q thrombin·BPTI complex, the structure of thrombin is virtually unaltered upon boophilin binding.
