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In contrast, α-kappa-ETA′, a similarly designed human kappa light chain-specific fusion protein, was only specifically active in combination with antibodies containing a human kappa light chain.
A large international study has shown that capecitabine is highly active in combination with oxaliplatin, achieving a response rate of 55%, median TTP of 7.7 months and overall survival of 19.5 months as first-line therapy (Cassidy et al, 2004).
In clinical evaluation, two phase II studies indicated that cetuximab was active in combination with irinotecan and as monotherapy in irinotecan-resistant patients (Saltz et al, 2001; Saltz et al, 2004).
Moreover, it has also proved to be active in combination with oxaliplatin-based regimens, both in the first (Tabernero et al, 2007) and successive lines of treatment (Souglakos et al, 2007) In all those studies, cetuximab was administered weekly with an initial intravenous infusion of 400 mg m−2 on day 1 with subsequent weekly doses of 250 mg m−2.
The fact that men and women remain at risk of HPV infection as long as they are sexually active, in combination with the lack of effective means to prevent HPV infection in sexually active people, requires vaccine-induced protection to be long-lived.
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Active filters are circuits that use an operational amplifier (op amp) as the active device in combination with some resistors and capacitors to provide an LRC-like filter performance at low frequencies.
The presence of a -CXHC- active site in combination with the three other determinants of enzymatic activity suggest that TaPDIL1-1, TandIL2-1 TaPDIL7-2 and TaPDIL7-2 would be involved in disulphide bond formation.
Flavopiridol is currently under active investigation in combination with other agents and as a means to eradicate minimal residual disease in patients following cytoreductive chemotherapy.
These data support the further evaluation of molecular targeted, systemically active agents in combination with DEB-TACE in a phase III setting.
We have developed the means to allow production of active ChABC in combination with a promising cell transplant therapy for SCI repair.
The proposed optimization strategy offers designers some flexibility in utilizing both passive and active means in combination with linear and non-linear components for improved vibration mounts.
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