Sentence examples for active in a substantial from inspiring English sources

Inhibition of PI3K/Akt/mTORC1 signaling may be effective in osteosarcoma, but further studies are required to determine whether this pathway is active in a substantial subgroup of this heterogeneous tumor.

In contrast, ectopic expression of dominant-active ROCK culminated in a substantial increase of MLC2 phosphorylation at actin bundles (Figure 2B).

Active Erk5 was present in a substantial number of samples, as well as in tumours from an animal breast cancer model.

However, in a substantial group of patients, especially the young and active, functional impairment and pain after this fracture can lead to invalidity [1, 2].

Combined with an average of three times difference in intake will result in a substantial difference in the potential benefits offered by these biologically active compounds.

A 2011 survey found that only 9percentt of Wikipedia editors identified as female, and a 2012 paper in American Behavioral Scientist, a peer-reviewed academic journal, found that the number of active Wikipedia editors dropped from around 50,000 in 2006 to about 35,000 in 2011, resulting in a substantial decrease in the quality of Wikipedia articles.

We also observed the co-localization of GFP and RFP in a substantial number of cells, indicating that the NXNL1 promoter construct is active in rods.

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Get active in a hobby.

Become active in a Christian church.

However, binding of the inhibitor in the active site leads to a substantial decrease in the motional amplitude of the flexible residues, due to the hydrophobic interactions with the side chain of Met531.