Sentence examples for active her from inspiring English sources

In this paper we discovered an interesting phenomenon: the NiFe hydroxide can be turned into an active HER material by incorporating fluoride into it.

The NiSe nanoparticles on the RGO-PI/CNT (NiSe-RGO-PI/CNT) film was employed directly as a highly active HER electrocatalyst.

Drugs that specifically target active HER dimerization or phosphorylation have been investigated both preclinically and in clinical trials.

A significant (exemestane vs tamoxifen) treatment-by-marker ('active HER signalling' vs cases without 'active HER signalling') interaction (HR=0.42; 95% CI, 0.27 0.65; P<0.001; Figure 2B) suggests that patients with active HER signalling do not derive benefit from early exemestane treatment.

Three papers in Nature Medicine [ 4- 6] give an insight into one way that active HER receptors may promote tumour growth.

In the present study we examined the importance of active HER signaling in breast tumor biopsies and paired metastases, by evaluating the expression of phosphorylated HER1, HER2, HER3, Erk, Akt and the total level of HER4 and HER2.

An optimized expression system capable of producing from 25to3535 mg of biologically active hER-E/F in 1 liter of cell culture was designed, and a simple, rapid purification protocol for hER-E/F produced in this system was developed.

In addition, we correlated the clinical course of disease of patients treated with trastuzumab with Her-2/ neu phosphorylation status to determine the clinical relevance of active Her-2/ neu signalling.

We here report that, in Her-2/ neu overexpressing tumours, increased serum Her-2/ neu ECD levels are indeed associated with active Her-2/ neu tyrosine kinase signalling, as represented by Tyr1248-phosphorylated Her-2/ neu.

In this context, it is interesting to note that the detection of increased serum levels of the Her-2/ neu ECD has been associated with increased resistance to endocrine therapy in Her-2/ neu overexpressing metastatic breast cancer (Lipton et al, 2002), thereby suggesting that resistance to antihormonal agents was associated with active Her-2/ neu-dependent signalling.

Since tyrosine kinase activation is the downstream mechanism of action for Her-2/ neu, it has been postulated that tumours exhibiting active Her-2/ neu signalling represented by phosphorylation of tyrosine residues might be those most sensitive to treatment with trastuzumab (DiGiovanna and Stern, 1995; Thor et al, 2000).