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This was done to confirm the activity of active extracts and to determine their IC50, IC100 and selectivity index (SI) values.
Approximately more than half of the active extracts (5) displayed antimicrobial activity against S. typhimurium.
Thus, eliminating such undesirable components in Nefang or selectively combining the active extracts might increase overall activity and tolerability as suggested elsewhere [ 58].
The top eight active extracts, with large spectra of activity, showed MIC values generally ranging from 128 to 512 μg/ml.
For active extracts, dose response experiments were performed to validate activity versus M. smegmatis.
The discrimination of active extracts is based on ranked levels of antiplasmodial activity proposed by Rasoanaivo et al. [ 41].
Some of the highly active extracts were further assessed for cytotoxicity and apoptotic activity at 48 hr.
However, the phytochemical constituents present in the active extracts and fractions, which are responsible for the observed activity, need to be further investigated.
However, among the active extracts, the dichloromethane root extract, CMRD exhibited high larvicidal activity with an LC50 value of 126.11 μg/mL than ethanolic root extracts, CMRE which had an LC50 value of 219.99 μg/mL.
The active extracts and constituents of TT could improve sexual function through activating aphrodisiacs and improving fertility in men.
This could be achieved by rapid acquisition of transcription profiles from active extracts that will point to potentially novel compounds.
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CEO of Professional Science Editing for Scientists @ prosciediting.com