Exact(8)
This study opens a new perspective of active delivery of antitumor drug against breast cancer and its lymph node metastases with inspiring therapeutic effect and little side effects.
Active delivery of recombinant autoantigens or allergens at the intestinal mucosa by genetically modified Lactococcus lactis (L lactis) provides a novel therapeutic approach for inducing tolerance.
The active delivery of probiotic cells in microencapsulated form has received reasonable attention during the last 10 years, since it can reduce losses of sensitive bacteria induced by detrimental external factors during storage and digestion [1].
Results: Intragastric administration of OVA-secreting L lactis led to active delivery of OVA at the mucosa and suppression of local and systemic OVA-specific T-cell responses in DO11.10 mice.
However, perfusion systems can provide continuous delivery of cell culture media to 3D tissue constructs, which promotes more active delivery of oxygen, soluble factors, and shear stress, which can be utilized to guide tissue maturation and functional remodeling of bioengineered tissues.
Results: Intragastric administration of TFF-secreting L. lactis led to active delivery of TFF at the mucosa of the colon and, in contrast to administration of purified TFF, proved to be very effective in prevention and healing of acute DSS-induced colitis.
Similar(52)
To our knowledge, we report the first successful demonstration of the active delivery, using macrophages, of nanoparticles to brain metastases and it paves the way for testing this method to deliver other nanovectors including nanorods, hollow nanospheres in the sub-100 and sub-50 nm range as well as nanoformulated therapeutics.
This would provide the proof of concept of active delivery vehicles able to guide their movement towards diseased cells.
These studies demonstrated that active targeted delivery of gemcitabine into tumors showed enhanced anti-tumor activity by successfully triggering the apoptotic pathway.
Two possibilities have been proposed for how this might occur: either the neurons that encode the tone remain active until delivery of the air puff, or different groups of neurons are successively activated in a relay that spans the interval between the tone and the air puff.
Folate (FA) was linked to the surface of micelles for the active target delivery of micelles to tumor cells.
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Justyna Jupowicz-Kozak
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